Clomiphene citrate at 50: the dawning of assisted reproduction

CLOMID® (clomiphene citrate tablets USP)

Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether. CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Each white scored tablet contains 50 m...

Clomiphene Citrate and Oocyte Quality

Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...

Use of clomiphene citrate in women.

I A T p d m c vulatory dysfunction is one of the most common causes of eproductive failure in sub-fertile and infertile couples. In the bsence of other significant infertility factors, successful vulation induction often will restore normal fertility. Cloiphene citrate (CC) is the best initial treatment for the large ajority of anovulatory infertile women. The first clinical rial of CC therapy ...

Catamenial haemoptysis and clomiphene citrate therapy.

Case reports of catamenial haemoptysis are uncommon. We report the first case of thoracic endometriosis associated with clomiphene citrate therapy and previously unpublished endobronchial and angiographic findings.

Ovulation induction with clomiphene citrate + gonadotropin + GnRH antagonist versus ovulation induction without clomiphene citrate in women submitted to assisted reproductive techniques